Neurobiology of Disease Dopamine, Corticostriatal Connectivity, and Intertemporal Choice
نویسندگان
چکیده
Andrew S. Kayser,1,2,3 Daicia C. Allen,1,2 Ana Navarro-Cebrian,1,2 Jennifer M. Mitchell,1,2 and Howard L. Fields1,2 1Department of Neurology, University of California, San Francisco, San Francisco, California 94143, 2Ernest Gallo Clinic and Research Center, Emeryville, California 94608, and 3Department of Neurology, Veterans Affairs Northern California Health Care System, Martinez, California 94553
منابع مشابه
Dopamine, corticostriatal connectivity, and intertemporal choice.
Value-based decisions optimize behavioral outcomes. Because delayed rewards are discounted, an increased tendency to choose smaller, immediate rewards can lead to suboptimal choice. Steep discounting of delayed rewards (impulsivity) characterizes subjects with frontal lobe damage and behavioral disorders including substance abuse. Correspondingly, animal studies and indirect evidence in humans ...
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Large individual differences exist in the ability to delay gratification for the sake of satisfying longer-term goals. These individual differences are commonly assayed by studying intertemporal preferences, as revealed by choices between immediate and delayed rewards. In the brain, reward-based and goal-oriented decisions are believed to rely on the striatum and its interactions with other cor...
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Choosing between smaller prompt rewards and larger later rewards is a common choice problem, and studies widely agree that frontostriatal circuits heavily innervated by dopamine are centrally involved. Understanding how dopamine modulates intertemporal choice has important implications for neurobiological models and for understanding the mechanisms underlying maladaptive decision-making. Howeve...
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■ Choosing between sooner smaller rewards and larger later rewards is a common choice problem, and studies widely agree that frontostriatal circuits heavily innervated by dopamine are centrally involved. Understanding how dopamine modulates intertemporal choice has important implications for neurobiological models and for understanding the mechanisms underlying maladaptive decision-making. Howe...
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Nigel S. Bamford,1,2,5 Siobhan Robinson,3 Richard D. Palmiter,3,4 John A. Joyce,1 Cynthia Moore,6 and Charles K. Meshul6 1Department of Neurology, 2Center on Human Development and Disability, 3Neurobiology and Behavior Program, and 4Howard Hughes Medical Institute, University of Washington, and 5Department of Pediatrics, Children’s Hospital and Regional Medical Center, Seattle, Washington 98195...
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